All Posts By

Tulya Kavaklioglu

Interview with GenomeScan’s CEO

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FASTER, BETTER, AFFORDABLE. BiotechNEWS has recently interviewed our CEO, Kees van den Berg. According to Kees, the future of diagnostics is all about personalized medicine. In this article (in Dutch), he describes the expansion of GenomeScan and the relationship with LUMC and ErasmusMC. He also highlights the current trends in NGS and comments on future developments in healthcare. Enjoy… Published…

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Five advantages of UMIs in DNA analysis

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Improvements in Gene Panel and Whole Exome sequencing Molecular barcoding refers to the attachment of a unique molecular sequence (eg. ATGCCA) to each individual DNA fragment in a sample. This ensures that in downstream analysis, unique sequence reads can be separated from those originating as a result of PCR duplication. A common practice regarding these PCR duplicates is to search…

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Four reasons why UMIs improve gene expression profiling

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Transcription profiles give accurate images of the biological processes that influence cell fates. However, library construction can introduce bias at multiple steps. For example, PCR amplification increases the number of cDNA molecules to an amount sufficient for sequencing, but also stochastically introduces errors and amplifies different molecules with unequal probabilities. The sequencing reads that have been created from the same…

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