The epigentics of melanoma. DNA is often methylated at the cytosine (C) base if the C is followed by a G base. Instead of a methylated or non-methylated C, one may also find 5-hydroxymethyl-C (hmC) at this position. GenomeScan has joined the MELGEN consortium to investigate the role of hmC in melanoma. Last month, Catarina Salgado and co-workers from the…
This article describes the results of a multidisciplinary prostate cancer study. Prof. dr. ir. Guido Jenster and his collaborators (NGS ProToCol consortium) showed that clinical roles of circular RNA’s are different from their linear counterparts, promoting cell proliferation in localized prostate cancer. GenomeScan contributed to the RNA sequencing and data processing. Read full article: https://www.sciencedirect.com/science/article/pii/S0092867419300583
Widespread and Functional RNA Circularizationin Localized Prostate Cancer Sujun Chen, Vincent Huang, Xin Xu, Julie Livingstone, Fraser Soares, Jouhyun Jeon, Yong Zeng, Junjie Tony Hua, Jessica Petricca, Haiyang Guo, Miranda Wang, Fouad Yousif, Yuzhe Zhang, Nilgun Donmez, Musaddeque Ahmed, Stas Volik, Anna Lapuk, Melvin L.K. Chua, Lawrence E. Heisler, Adrien Foucal, Natalie S. Fox, Michael Fraser, Vinayak Bhandari, Yu-Jia Shiah,…
Consensus molecular subtype classification of colorectal adenomas. Komor MA, Bosch LJ, Bounova G, Bolijn AS, Delis-van Diemen PM, Rausch C, Hoogstrate Y, Stubbs AP, de Jong M, Jenster G, van Grieken NC, Carvalho B, Wessels LF, Jimenez CR, Fijneman RJ, Meijer GA; NGS-ProToCol Consortium:. J Pathol. 2018 Nov;246(3):266-276.
Functional characterization of a multi-cancer risk locus on chr5p15.33 reveals regulation of TERT by ZNF148. Fang J, Jia J, Makowski M, Xu M, Wang Z, Zhang T, Hoskins JW, Choi J, Han Y, Zhang M, Thomas J, Kovacs M, Collins I, Dzyadyk M, Thompson A, O’Neill M, Das S, Lan Q, Koster R; PanScan Consortium; TRICL Consortium; GenoMEL Consortium, Stolzenberg-Solomon…
Draft Genome Sequence of the Basidiomycete White-Rot Fungus Phlebia centrifuga. Mäkelä MR, Peng M, Granchi Z, Chin-A-Woeng T, Hegi R, van Pelt SI, Ahrendt S, Riley R, Hainaut M, Henrissat B, Grigoriev IV, de Vries RP, Hildén KS. Genome Announc. 2018 Apr 5;6(14). pii: e01414-17.
Talaromyces borbonicus, sp. nov., a novel fungus from biodegraded Arundo donax with potential abilities in lignocellulose conversion. Varriale S, Houbraken J, Granchi Z, Pepe O, Cerullo G, Ventorino V, Chin-A-Woeng T, Meijer M, Riley R, Grigoriev IV, Henrissat B, de Vries RP, Faraco V. Mycologia. 2018 Mar-Apr;110(2):316-324.
Draft Genome Sequence of Talaromyces adpressus. Cerullo G, Houbraken J, Granchi Z, Pepe O, Varriale S, Ventorino V, Chin-A-Woeng T, Meijer M, de Vries RP, Faraco V. Genome Announc. 2018 Jan 11;6(2).
Coding and small non-coding transcriptional landscape of tuberous sclerosis complex cortical tubers: implications for pathophysiology and treatment. Mills JD, Iyer AM, van Scheppingen J, Bongaarts A, Anink JJ, Janssen B, Zimmer TS, Spliet WG, van Rijen PC, Jansen FE, Feucht M, Hainfellner JA, Krsek P, Zamecnik J, Kotulska K, Jozwiak S, Jansen A, Lagae L, Curatolo P, Kwiatkowski DJ, Pasterkamp…
Critical points for an accurate human genome analysis. White SJ, Laros JFJ, Bakker E, Cambon-Thomsen A, Eden M, Leonard S, Lochmüller H, Matthijs G, Mattocks C, Patton S, Payne K, Scheffer H, Souche E, Thomassen E, Thompson R, Traeger-Synodinos J, Van Vooren S, Janssen B, den Dunnen JT. Hum Mutat. 2017 Aug;38(8):912-921.
Detecting PKD1 variants in polycystic kidney disease patients by single-molecule long-read sequencing. Borràs DM, Vossen RHAM, Liem M, Buermans HPJ, Dauwerse H, van Heusden D, Gansevoort RT, den Dunnen JT, Janssen B, Peters DJM, Losekoot M, Anvar SY. Hum Mutat. 2017 Jul;38(7):870-879.
Differentiation-Defective Human Induced Pluripotent Stem Cells Reveal Strengths and Limitations of the Teratoma Assay and In Vitro Pluripotency Assays. Bouma MJ, van Iterson M, Janssen B, Mummery CL, Salvatori DCF, Freund C. Stem Cell Reports. 2017 May 9;8(5):1340-1353.
Integrative analysis of extracellular and intracellular bladder cancer cell line proteome with transcriptome: improving coverage and validity of -omics findings. Latosinska A, Makridakis M, Frantzi M, Borràs DM, Janssen B, Mullen W, Zoidakis J, Merseburger AS, Jankowski V, Mischak H, Vlahou A. Sci Rep. 2016 May 11;6:25619
Recent Comments