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The epigentics of melanoma.

DNA is often methylated at the cytosine (C) base if the C is followed by a G base. Instead of a methylated or non-methylated C, one may also find 5-hydroxymethyl-C (hmC) at this position. GenomeScan has joined the MELGEN consortium to investigate the role of hmC in melanoma. Last month, Catarina Salgado and co-workers from the MELGEN consortium have published results showing significantly decreased hmC levels in melanoma. The depletion of hmC was more pronounced in metastatic than in non-metastatic tumours. Hence, the distinction of methyl-C and hmC – a  validated service offered by GenomeScan – may help to understand cancer.

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