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Whole Genome Sequencing

Uniform coverage of your sample sequence
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WGS service header Whole Genome Sequencing

Why sequence a genome?

Whole Genome Sequencing (WGS) is a powerful tool when investigating rare diseases of unknown causes, and for exploratory studies that involve regulatory elements or structural variation.

Mirjam Rademaker Whole Genome Sequencing
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Main advantages of WGS

In comparison to Whole Exome Sequencing (WES), which focuses only on the protein-coding regions of the genome, WGS provides a close to full coverage of the genome.

Because of this, WGS is preferred by many researchers who aim to dig deep into these large sets of data, to explore the remaining largely unexplored variations.

  • PCR-free library preparation including unique dual indexing (UDIs) and unique molecular identifiers (UMIs)
  • Accurate representation of GC-rich gene sequences
  • SNP, Indel and CNV analysis possible
  • Uniform coverage of the complete genome
  • De-novo sequencing of previously unexplored genomes, including non-coding regions
  • Possibility to re-examine genomic regions in the future with new knowledge

Whole Genome Sequencing Resources



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Service workflow

Data analysis

As a result of WGS, ~165 Gb of data per human genome is produced. This presents challenges of extracting meaningful information and interpreting it. However, our experienced bioinformaticians at GenomeScan can apply optimized workflows for analyzing your dataset, and help you receive reliable and publication-ready results.

Whole Metagenome Shotgun Sequencing

When it comes to profiling microbial communities in a sample, sequencing whole genomes (whole metagenome shotgun sequencing) is an opportunity that presents particular advantages. Especially because of the use of PCR-free library preparation including unique dual indexing (UDIs) and unique molecular identifiers (UMIs). Read more about this technique here.

WGS product specification 1 Whole Genome Sequencing
Service specifications

We have summarized key information about our whole genome sequencing service into a service specification sheet.

Download sheet

Other Services

Whole Exome Sequencing
Long read sequencing
Total transcriptome
Whole microbiome
Gene expression analysis
Ultra low input RNA seq

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