Whole Genome Sequencing (WGS)

Whole Genome Sequencing

Uniform coverage of your sample sequence

Whole Genome Sequencing (WGS) is a particularly powerful tool when investigating rare diseases of unknown causes, and for exploratory studies that involve regulatory elements or structural variation.

Whole Genome Sequencing (WGS)

In comparison to Whole Exome Sequencing (WES), which focuses only on the protein-coding regions of the genome, WGS provides a wider coverage and more comprehensive insight into the entirety of the genome. Because of this, WGS is preferred by many researchers who aim to dig deep into these large sets of data, to explore the remaining largely unexplored structural variations.

PCR-free library preparation including unique dual indexing (UDIs) and unique molecular identifiers (UMIs)

Accurate representation of GC-rich gene sequences

De-novo sequencing of previously unexplored genomes

Uniform coverage of the complete genome, including non-coding regions

SNP, Indel and CNV analysis possible

Possibility to re-examine genomic regions in the future with new knowledge

Data analysis

As a result of WGS, ~165 Gbps of data per human genome is produced. This presents challenges of extracting meaningful information and interpreting it. However, our experienced bioinformaticians at GenomeScan can apply optimized workflows for analyzing your dataset, and help you receive reliable and publication-ready results.

Whole Metagenome Shotgun Sequencing

When it comes to profiling microbial communities in a sample, sequencing whole genomes (whole metagenome shotgun sequencing) is an opportunity that presents particular advantages. Especially because of the use of PCR-free library preparation including unique dual indexing (UDIs) and unique molecular identifiers (UMIs). Read more about this technique here.