Epigenetic services using Micro-array and Next Generation Sequencing
Epigenetics research focuses on biological or chemical influences that can change the expression of a gene. “Epi” is greek for “above or outside”, referring to the modifications such as methylation or hydroxymethylation that are attached to the DNA strands. Because the various epigenetic groups have different effects on the gene transcription, measuring these specific groups is important when explaining various (disease) phenotypes.
We are a leading service provider for Epigenetics studies in Europe. Our wide portfolio enables you to select the most optimal method for your project. The available products range from cost-effective array-based techniques to targeted methylome sequencing methods.
With our validated applications you have the tools in hand to study different methylation loci in the most challenging samples: low quality or quantity of the available DNA is no longer hampering your project. EpiRestore™ reproducibly determines the methylation status in degraded FFPE material. Furthermore, with our SeqCap Epi procedure, we can reliably detect up to 5.5 million CpG’s with only 10 ng starting material.
All of these products are part of our ISO/IEC 17025 (L518) accreditation, which guarantees a standard high data-quality. Our dedicated methylation product specialists can help you design the most optimal research strategy. Contact us for free expert advice. We set the standard for sharply priced array and NGS methylation sequencing services.
|EpiRestore in combination
|Whole Genome Bisulfite Sequencing (WGBS)||Reduced Representation
Bisulfite Sequencing (RRBS)
|Organisms||Human only||Human only||All||All|
|Tissue of highest abundance||All||All||All||All|
|Methylated targets||850,000 selected loci||850,000 selected loci||All||Majority of loci|
|Validated and within ISO 17025 accreditation scope||✓||✓||✓||✓|
|Applicable for FFPE samples||✓||✓||–||–|
|Costs||Very budget friendly||Budget friendly||Best option for a wide methylome view||More economical than whole genome sequencing|
|Benefits||Best option for a cost-effective focused approach||Only method to study highly degraded DNA||Unbiased approach for methylation research||Benefits of WGBS but with reduced costs|
|Mostly used for||EWAS studies or large cohorts||Analysis of FFPE cohorts or Guthry cards||In-depth analysis of selected patient samples||Discovery research projects|