Epigenetics

The leading service provider for (hydroxy)methylation studies in Europe

Epigenetic services using Micro-array and Next Generation Sequencing

We are a leading service provider for Epigenetics studies in Europe. Our wide portfolio enables you to select the most optimal method for your project. The available products range from cost-effective array-based techniques to targeted methylome sequencing methods.

All of these products are part of our ISO/IEC 17025 (L518) accreditation, which guarantees a standard high data-quality. Our dedicated methylation product specialists can help you design the most optimal research strategy. Contact us for free expert advice.

Next Level Epigenetics

With our validated applications you have the tools in hand to study different methylation loci in the most challenging samples: low quality or quantity of the available DNA is no longer hampering your project. EpiRestore™ reproducibly determines the methylation status in degraded FFPE material. Furthermore, with our SeqCap Epi procedure, we can reliably detect up to 5.5 million CpG’s with only 10 ng starting material.

We set the standard for sharply priced array and NGS methylation sequencing services.

Epigenetics research focuses on biological or chemical influences that can change the expression of a gene. “Epi” is greek for “above or outside”, referring to the modifications such as methylation or hydroxymethylation that are attached to the DNA strands. Because the various epigenetic groups have different effects on the gene transcription, measuring these specific groups is important when explaining various (disease) phenotypes.

Reduced Representation & Whole Genome Bisulfite Sequencing

Hydroxymethylation

Targeted methylation

MethylationEPIC ‘850K’ BeadChip

EpiRestore: restore all low integrity DNA

Choose the most optimal method for your project

MethylationEPIC

BeadChip 

 EpiRestore in combination with MethylationEPIC Hydroxymethylation 

by MethylationEPIC

 SeqCap Epi using CpGiant Enrichment Whole Genome Bisulfite Sequencing (WGBS) Reduced Representation Bisulfite Sequencing (RRBS)
Organisms Human only Human only Human only Human only All All
Tissue of highest abundance All All Neuronal cells, stem cells, cancer tissue All All All
Methylated targets 850,000 selected loci 850,000 selected loci 850,000 selected loci 5.5 million selected loci All Majority of loci
Validated and within ISO 17025 accreditation scope ✓ ✓ ✓ In progress ✓ ✓
Applicable for FFPE samples ✓ ✓ ✓ ✓ – –
Costs Very budget friendly Budget friendly Best option for hmC research Economical tool for a broad overview of mC loci Best option for a wide methylome view More economical than whole genome sequencing
Benefits Best option for a cost-effective focused approach Only method to study highly degraded DNA Sole method to discriminate between hmC and mC Large number of CpG sites and low input possible Unbiased approach for methylation research Benefits of WGBS but with reduced costs
Mostly used for EWAS studies or large cohorts Analysis of FFPE cohorts or Guthry cards Large cohorts or EWAS studies for neuronal diseases Drug development

Low input samples
Discovery outside of published loci

 In-depth analysis of selected patient samples Discovery research projects
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ServiceXS is our research department for genetic analyses. Our scientists constantly test and develop technologies and applications to stay one step ahead in genetic testing. We offer a wide range of applications for veterinary, agriculture, microbial and medical research.