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Meta-analysis of polycystic kidney disease expression profiles defines strong involvement of injury repair processes.

Malas TB, Formica C, Leonhard WN, Rao P, Granchi Z, Roos M, Peters DJ, ‘t Hoen PA.

Am J Physiol Renal Physiol. 2017 Apr 1;312(4):F806-F817.

This article is published with contributions of GenomeScan.

“In this study, we present the first RNASeq analysis of a Pkd1-mutant mouse model in a combined meta-analysis with other published PKD expression profiles. We introduce the PKD Signature, a set of 1,515 genes that are commonly dysregulated in PKD studies.”

“We propose that compounds that can modulate the injury-repair response could be valuable drug candidates for PKD treatment.”

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