Funding scheme:

FP7-PEOPLE-ITN-2008 – Grant Agreement ID 238278

Time frame:

1 October 2009 to 30 September 2013

Weblink:

http://www.pro-nest.org/
CORDIS: https://cordis.europa.eu/project/id/238278

Description:

The PRO-NEST training programme consisted of individual research projects that were embedded in the PRO-NEST research programme. Research focused on the understanding of the molecular events responsible for the initiation and progression of prostate cancer (PCa) as well as on the development of novel biomarkers and therapeutic targets with the ultimate goal to improve the diagnosis, prognosis, treatment and prevention of this major European health problem. Within this framework, GenomeScan supervised the training of an experienced researcher (ER), hosted several secondments, and contributed to the development of sensitive methods to detect novel DNA and RNA fusions in PCa.

Output:

Next-generation sequencing reveals novel rare fusion events with functional implication in prostate cancer. Teles Alves, I., Hartjes, T., McClellan, E. et al. Oncogene 34, 568–577 (2015). doi: 10.1038/onc.2013.591

The molecular signature of the stroma response in prostate cancer-induced osteoblastic bone metastasis highlights expansion of hematopoietic and prostate epithelial stem cell niches. Özdemir BC, Hensel J, Secondini C, Wetterwald A, et al. PLoS One.;9(12):e114530 (2014). doi: 10.1371/journal.pone.0114530

Acknowledgements:

This project has received funding from the European Union’s Seventh Framework Programme (FP7/2007-2013) under grant agreement No 238278.