Long Read Sequencing

Genomic, transcriptomic and epigenetic characterization with high precision

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Retrieving sequencing reads up to 175.000 base pairs, long read sequencing overcomes the challenges that short-reads have in difficult regions present such as repetitive elements and large structural variations.

Long Read Sequencing

Next generation sequencing (NGS) technologies typically make use of generating 75-300bp long reads, which are then either de-novo assembled in a genome or mapped to a reference genome. Complex regularity elements or highly repetitive sequences can make this mapping harder than for uniquely variable ones. By utilizing SMRT technology of the PacBio Sequel II system, we are able to generate reads up to 175.000 bp and analyze your samples with high precision.

De-novo sequencing of previously uncharacterized genomes particularly benefits from long-read sequencing. It provides a powerful tool for analyzing variable number tandem repeats, or for repeat occurrence with disease significance, such as in Huntington’s disease.

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Easier assembly of complete genomes
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Sequencing full-length RNA transcripts
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Direct detection of epigenetic modifications
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Haplotype phasing information
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Base-level resolution with >99% single-molecule read accuracy
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Unbiased coverage of GC rich regions such as promoters
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No PCR amplification, prevention of errors

Data analysis

GenomeScan’s bioinformatics experts apply optimized pipelines for preprocessing, assemblies, variant calling and disease annotations to analyze your dataset. With our customizable workflows, we help you receive reliable and publication-ready results.

Bioinformatic pipelines can also be tailored according to your research or clinical needs allowing more in-depth mining of your dataset.

How it works

We have summarized key information about our long read sequencing service into a product specification sheet, which you can download here.

Discuss your project with Andre

We have years of experience in the field. Talk with us about best practices and how we can help your research.

Pricing

Competitive pricing for unmatched quality

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Andre Wijfjes

Manager Customer Support