EU-Funded Project





Optimized esterase biocatalysts for cost-effective industrial production.

In short:

Multinational project on identifying novel enzymes derived from bacteria and fungi.


Pharma/biotech, Innovation

Pharma biotech OPTIBIOCAT Innovation OPTIBIOCAT

Project Details

Funding scheme:

FP7-KBBE-2013-7 – Grant Agreement ID 613868

Time frame:

1 December 2013 to 30 November 2017



The cosmetics industry needs more sustainable, eco-friendly, and cost-effective technologies. Towards this goal, the OPTIBIOCAT project identified novel enzymes from bacteria and fungi that can produce ingredients with antioxidant activity. An impressive portfolio of new enzymes was developed including more than 550 novel glucuronoyl esterases (GEs) and 500 putative feruloyl esterases (FAEs) identified from fungal and bacteria genomes by bioinformatics analyses, to which GenomeScan contributed significantly by sequencing and de novo assembly of multiple fungal genomes.


Draft genome sequence of the Basidiomycete white-rot fungus Phlebia centrifuga. Mäkelä MR, et al. Genome Announc. 2018 Apr 5;6(14):e01414-17. doi: 10.1128/genomeA.01414-17

Genome Sequence of the Thermophilic Biomass-Degrading Fungus Malbranchea cinnamomea FCH 10.5. Granchi Z, et al. Genome Announc. 2017 Aug 17;5(33):e00779-17. doi: 10.1128/genomeA.00779-17

The draft genome sequence of the ascomycete fungus Penicillium subrubescens reveals a highly enriched content of plant biomass related CAZymes compared to related fungi. Peng M, et al. Journal of biotechnology. 2017 Mar 20;246:1-3. doi: 10.1016/j.jbiotec.2017.02.012

Genome sequence of the basidiomycete white-rot fungus Trametes pubescens FBCC735. Granchi Z, et al. Genome Announc. 2017 Feb 23;5(8):e01643-16. doi: 10.1128/genomeA.01643-16

Talaromyces borbonicus, sp. nov., a novel fungus from biodegraded Arundo donax with potential abilities in lignocellulose conversion. Varriale S, et al. Mycologia. 2018 Mar 4;110(2):316-24. doi: 10.1080/00275514.2018.1456835

Draft genome sequence of Talaromyces adpressus. Cerullo G, et al. Genome Announc. 2018 Jan 11;6(2):e01430-17. doi: 10.1128/genomeA.01430-17

Genome sequence of Rhizomucor pusillus FCH 5.7, a thermophilic zygomycete involved in plant biomass degradation harbouring putative GH9 endoglucanases. Hüttner S, et al. Biotechnology Reports. 2018 Dec 1;20:e00279. doi: 10.1016/j.btre.2018.e00279

Combined genome and transcriptome sequencing to investigate the plant cell wall degrading enzyme system in the thermophilic fungus Malbranchea cinnamomea. Hüttner S, et al. Biotechnology for biofuels. 2017 Dec;10(1):265. doi: 10.1186/s13068-017-0956-0


EU OPTIBIOCAT This project has received funding from the European Union’s Seventh Framework Programme (FP7/2007-2013) under grant agreement No 613868.