Find statistically relevant biomarkers in tissue that has been stored in paraffin for decades.
Measuring epigenetic markers in paraffin embedded (FFPE) blocks is challenging. Fixation extensively damages and shreds DNA. The nucleotides of these DNA fragments also become altered by processes such as depurination and de-amination.
The EpiRestore™ service restores heavily degraded DNA so it can be analyzed using Illumina’s MethylationEPIC micro-array. Moreover, our modified hybridization protocol allows you to start with as little as 200 ng of DNA. You can harvest a wealth of data of previously unattainable patient cohorts.